Lisa Murkowski is conceding the senate primary in Alaska to RedState and Sarah Palin endorsed Joe Miller.

This news is bigger than Lisa Murkowski. While Establishment Republicans will bristle at it, this is a near total kneecapping of Senate Republican Leader Mitch McConnell, not to mention another rejection of the National Republican Senatorial Committee.

Consider this inside baseball fact: McConnell has chosen as his loyal lieutenants at the leadership table Robert Bennett (R-UT), Judd Gregg (R-NH), Lisa Murkowski (R-AK), and Kay Bailey Hutchison (R-TX).

Judd Gregg is retiring and McConnell sought to replace him with Trey Grayson of Kentucky. Grayson, however, lost to Rand Paul in the Kentucky GOP Primary.

Conservatives threw Bob Bennett out at the Utah GOP convention, replacing him with firebrand conservative Mike Lee.

Now Lisa Murkowski is defeated, like Bob Bennett, by conservative activists concerned by the fiscal drift of the Republican Party and the overall direction of the American republic.

Consider another fact: Conservatives, led by Jim DeMint and Sarah Palin, are potentially creating the most conservative Senate Republican Conference in the last thirty or so years: Sharron Angle, Ken Buck, Mike Lee, Joe Miller, Rand Paul, Marco Rubio, and Pat Toomey will be joining Jim DeMint, Tom Coburn, and David Vitter.